160579-78-2

Basic information

• Product Name: 2R-t-butyldiphenylsilyloxymethyl-4R-(N-4'-acetylcytosin-1'-yl)-1,3-oxathiolane
• CAS NO: 160579-78-2
• Molecular Weight: 509.701
• Mol File: 160579-78-2.mol

Chemical Properties

• CAS DataBase Reference: 2R-t-butyldiphenylsilyloxymethyl-4R-(N-4'-acetylcytosin-1'-yl)-1,3-oxathiolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2R-t-butyldiphenylsilyloxymethyl-4R-(N-4'-acetylcytosin-1'-yl)-1,3-oxathiolane(160579-78-2)
• EPA Substance Registry System: 2R-t-butyldiphenylsilyloxymethyl-4R-(N-4'-acetylcytosin-1'-yl)-1,3-oxathiolane(160579-78-2)

Safety Data

• Hazardous Substances Data: 160579-78-2(Hazardous Substances Data)

Upstream product

• 133120-44-2 N-(2-Oxo-1-trimethylsilanyl-1,2-dihydro-pyrimidin-4-yl)-acetamide 
• 186707-06-2 Trans and Cis-2R-t-butyldiphenylsilyloxymethyl-4-acetoxy-1,3-oxathiolane 
• 160579-76-0 tert-Butyl-((R)-3-oxo-3λ⁴-[1,3]oxathiolan-2-ylmethoxy)-diphenyl-silane 
• 160579-75-9 2R-t-butyldiphenylsilyloxymethyl-1,3-oxathiolane 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 160707-69-7 lamivudine 

Relevant articles and documents

Substituted 1,3-oxathiolanes with antiviral properties

This invention relates to single enantiomers of novel cis-substituted 1,3-oxathiolanes, of the formula (I): wherein; R1is hydrogen, and R2is cytosine or 5-fluorocytosine; and pharmaceutically acceptable salts and esters thereof. This invention also relates to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents, particularly in combination therapy.

Synthesis of Optically Active 2',3'-Dideoxy-3'-oxa-4'-thio-ribonucleoside Analogues by Transposition of a Leaving Group on Chiral Oxathiolanes via a Reductive-oxidative Process

The synthesis of chiral nucleoside analogues with a unique structural feature is reported.The strategy is based on a reductive-oxidative process to complete the transposition of the leaving group in chiral oxathiolanes with known configuration.