160590-01-2Relevant academic research and scientific papers
Two-step route to indoles and analogues from haloarenes: A variation on the Fischer indole synthesis
Inman, Martyn,Carbone, Anna,Moody, Christopher J.
, p. 1217 - 1232 (2012/03/26)
In a new variation on the Fischer indole synthesis, readily available haloarenes are converted into a wide range of indoles in just two steps by halogen-magnesium exchange and quenching with di-tert-butyl azodicarboxylate, followed by reaction with aldehy
Synthesis of 4- and 6-azaindoles via the fischer reaction
Jeanty, Matthieu,Blu, Jerome,Suzenet, Franck,Guillaumet, Gerald
supporting information; experimental part, p. 5142 - 5145 (2009/12/28)
Contrary to the common idea that Fischer indole cyclization often cannot be effectively applied to the synthesis of the corresponding azaindoles, we show that this approach can be actually very efficient for the formation of 4- and 6-azaindoles bearing an electron-donating group on the starting pyridylhydrazines. Two 4-azaindole natural product analogues were synthesized in a few steps and very good overall yields.
