1606137-80-7Relevant academic research and scientific papers
Synthesis and antimetastatic effects of E-salignone amide derivatives
Wang, Hong-Ling,Qin, Nan,Liu, Jia,Jin, Mei-Na,Zhang, Xiang,Jin, Mei-Hua,Kong, Dexin,Jiang, Shen-De,Duan, Hong-Quan
, p. 76 - 87 (2014)
Preclinical Research The preparation of novel E-salignone derivatives and their biological evaluation as potential antimetastatic agents is described. The E-salignone amide derivatives were prepared from epiandrosterone and androsterone, and characterized by analytical 1H NMR, 13C NMR, and mass spectrometry. The derivatives were evaluated for antimetastatic activity in MDA-MB-231 cells by using a transwell assay. Comparing with the positive control, LY294002, compounds 19b, 19d, and 19e exhibited significant inhibitory effects on the EGF-induced invasion of MB-MDA-231 cells. Moreover, compound 19b also had antimigration effects in wound-healing assay. Compound 19b may represent a novel antimetastatic agent for treating breast cancer.
