1606169-47-4

Basic information

• Product Name: C₁₂H₁₈NO₈PS
• Synonyms: C₁₂H₁₈NO₈PS
• CAS NO: 1606169-47-4
• Molecular Weight: 367.317
• Mol File: 1606169-47-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₈NO₈PS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₈NO₈PS(1606169-47-4)
• EPA Substance Registry System: C₁₂H₁₈NO₈PS(1606169-47-4)

Safety Data

• Hazardous Substances Data: 1606169-47-4(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 20074-79-7 diethyl (4-aminobenzyl)phosphonate 
• 1606168-61-9 diethyl (4-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}benzyl)phosphonate 
• 1606168-65-3 diethyl (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}benzyl)phosphonate 
• 1606168-69-7 diethyl (4-{[6-(3-aminophenyl)pyrimidin-4-yl]amino}benzyl)phosphonate 
• 1606168-73-3 (4-{[6-(3-nitrophenyl)pyrimidin-4-yl]amino}benzyl)phosphonic acid 
• 1606168-75-5 (4-{[6-(3-aminophenyl)pyrimidin-4-yl]amino}benzyl)phosphonic acid 

Relevant articles and documents

Synthesis and evaluation of phosphorus containing, specific CDK9/CycT1 inhibitors

Although there is a significant effort in the design of a selective CDK9/CycT1 inhibitor, no compound has been proven to be a specific inhibitor of this kinase so far. The aim of this research was to develop novel and selective phosphorus containing CDK9/CycT1 inhibitors. Molecules bearing phosphonamidate, phosphonate, and phosphinate moieties were synthesized. Prepared compounds were evaluated in an enzymatic CDK9/CycT1 assay. The most potent molecules were tested in cell-based toxicity and HIV proliferation assays. Selectivity of shortlisted compounds against CDKs and other kinases was tested. The best compound was shown to be a highly specific, ATP-competitive inhibitor of CDK9/CycT1 with antiviral activity.