1606175-74-9

Upstream product

• 75408-89-8 4-acetylbiphenyl oxime 
• 1079-66-9 chloro-diphenylphosphine 
• 92-91-1 biphenyl-4-acetaldehyde 

Downstream Products

• 1613309-94-6 (4R,5S)-diphenylmethyl 1-(diphenylphosphoryl)-5-(biphen-4-yl)-5-methyl-4,5-dihydro-1H-imidazole-4-carboxylate 
• 1613309-56-0 (4R,5S)-diphenylmethyl 5-(biphenyl-4-yl)-1-(diphenylphosphoryl)-5-methyl-4,5-dihydro-1H-imidazole-4-carboxylate 

Relevant academic research and scientific papers

Direct catalytic enantio- and diastereoselective Mannich reaction of isocyanoacetates and ketimines

A catalytic asymmetric synthesis of imidazolines with a fully substituted β-carbon atom by a Mannich-type addition/cyclization reaction of isocyanoacetate pronucleophiles and N-diphenylphosphinoyl ketimines has been developed. When a combination of a cinchona-derived aminophosphine precatalyst and silver oxide was employed as a binary catalyst system, good reactivity, high diastereoselectivities (up to 99:1 d.r.), and excellent enantioselectivities (up to 99 % ee) were obtained for a range of substrates. Binary catalyst system: A catalytic asymmetric synthesis of imidazolines with a fully substituted β-carbon atom through a Mannich-type addition/cyclization reaction of isocyanoacetate pronucleophiles and N-diphenylphosphinoyl ketimines has been developed. By employing a cinchona-derived aminophosphine precatalyst and silver oxide as a binary catalyst system, good reactivity and high diastereo- and enantioselectivities were obtained.