1606178-91-9Relevant academic research and scientific papers
One-pot synthesis of ureas from Boc-protected amines
Spyropoulos, Constantinos,Kokotos, Christoforos G.
, p. 4477 - 4483 (2014)
A practical one-pot synthesis of ureas is described. Boc-protected amines can be transformed into nonsymmetrical and symmetrical disubstituted and trisubstituted ureas utilizing 2-chloropyridine and trifluoromethanesulfonyl anhydride for the in situ generation of an isocyanate, which reacts with an amine. A variety of amines can be employed successfully, leading to high yields of isolated ureas.
