1606590-32-2Relevant academic research and scientific papers
Cobalt-Catalyzed Intramolecular Alkyne/Benzocyclobutenone Coupling: C-C Bond Cleavage via a Tetrahedral Dicobalt Intermediate
Zhu, Zixi,Li, Xinghan,Chen, Sicong,Chen, Peng-Hao,Billett, Brent A.,Huang, Zhongxing,Dong, Guangbin
, p. 845 - 849 (2018)
A Co(0)-catalyzed intramolecular alkyne/benzocyclobutenone coupling through C-C cleavage of benzocyclobutenones is described. Co2(CO)8/P[3,5-(CF3)2C6H3]3 was discovered to be an effective metal/ligand combination, which exhibits complementary catalytic activity to the previously established rhodium catalyst. In particular, the C8-substituted substrates failed in the Rh system, but succeeded with the Co catalysis. Experimental and computational studies show that the initially formed tetrahedral dicobalt-alkyne complex undergoes C1-C2 activation via oxidative addition with Co(0), followed by migratory insertion and reductive elimination to give the β-naphthol products.
Divergent syntheses of fused β-naphthol and indene scaffolds by rhodium-catalyzed direct and decarbonylative alkyne-benzocyclobutenone couplings
Chen, Peng-Hao,Xu, Tao,Dong, Guangbin
supporting information, p. 1674 - 1678 (2014/03/21)
A tunable rhodium-catalyzed intramolecular alkyne insertion reaction proceeding through the C-C cleavage of benzocyclobutenones is described. Selective formation of either the direct or decarbonylative insertion product can be controlled by using different catalytic systems. A variety of fused β-naphthol and indene scaffolds were obtained in good yields with high functional group tolerance. This work illustrates a divergent approach to synthesize fused-ring systems by C-C activation/functionalization. Cat. in control: A tunable rhodium-catalyzed intramolecular alkyne insertion reaction proceeding through C-C cleavage of benzocyclobutenones is described. Selective formation of either the direct or decarbonylative insertion product can be controlled by using different catalytic systems. A variety of fused β-naphthol and indene scaffolds were obtained in good yields with high functional-group tolerance. Copyright
