16066-93-6

Usage

Uses

Used in Pharmaceutical Research:
1-(5-amino-1H-indol-1-yl)ethanone is used as a research chemical for studying the effects of serotonin reuptake inhibition on the central nervous system. Its psychoactive properties make it a valuable tool in understanding the mechanisms of mood, perception, and cognition alterations.
Used in Recreational Drug Culture:
1-(5-amino-1H-indol-1-yl)ethanone is used as a recreational drug for its euphoric and empathogenic effects. However, it is associated with various adverse side effects and potential health risks, which has led to its classification as a controlled substance in many countries, with strict regulations on its use.
Used in Toxicological Studies:
Due to its psychoactive nature and potential for abuse, 1-(5-amino-1H-indol-1-yl)ethanone is utilized in toxicological research to investigate the adverse effects and health risks associated with its consumption, aiming to inform regulatory policies and public health strategies.

Upstream product

• 6146-52-7 5-nitroindole 
• 4769-98-6 1-(5-nitro-1H-indol-1-yl)ethan-1-one 

Downstream Products

• 495-48-7 azoxybenzene 

Relevant academic research and scientific papers

Calculated oxidation potentials predict reactivity in Baeyer-Mills reactions

Azobenzenes are widely used as dyes and photochromic compounds, with the Baeyer-Mills reaction serving as the most common method for their preparation. This transformation is often plagued by low yields due to the formation of undesired azoxybenzene. Here, we explore electronic effects dictating the formation of the azoxybenzene side-product. Using calculated oxidation potentials, we were able to predict reaction outcomes and improve reaction efficiency simply by modulating the oxidation potential of the arylamine component.

Indole derivatives or salts thereof as well as preparation method and application of indole derivatives or salts thereof

The invention belongs to the technical field of chemical medicine, and relates to an Hh (Hedgehog) signal pathway Smoothed (SMO) receptor small molecule inhibitor, in particular to indole derivativesor salts thereof with Smoothed inhibitory activity, which are shown in chemical general formula (I) in the description, as well as a preparation method and pharmaceutical composition of the indole derivatives or salts thereof. Tests on inhibitory activity of Hh signal pathways show that most compounds have better inhibitory activity on the Hh signal pathways. The invention further discloses the application of the compounds to preparation of medicines for treating diseases associated with Hh, wherein the diseases are BCC (basal cell carcinoma), MB (medullblastoma), SCLC (small cell lung cancer), medulloblastoma, rhabdomyosarcoma, or a combination of the diseases.

HETEROCYCLE-SUBSTITUTED CYCLIC UREA DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS

The invention relates to the novel products of formula (I), in which V represents a heterocyclic radical, as protein kinases inhibitors.