1606973-42-5

Basic information

• Product Name: 5-((6-(3-chlorophenyl)-4-cyclopropyl-4,5-dihydro-1,3,5-triazin-2-yl)amino)piperidin-2-one
• Synonyms: 5-((6-(3-chlorophenyl)-4-cyclopropyl-4,5-dihydro-1,3,5-triazin-2-yl)amino)piperidin-2-one
• CAS NO: 1606973-42-5
• Molecular Weight: 345.832
• Mol File: 1606973-42-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-((6-(3-chlorophenyl)-4-cyclopropyl-4,5-dihydro-1,3,5-triazin-2-yl)amino)piperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-((6-(3-chlorophenyl)-4-cyclopropyl-4,5-dihydro-1,3,5-triazin-2-yl)amino)piperidin-2-one(1606973-42-5)
• EPA Substance Registry System: 5-((6-(3-chlorophenyl)-4-cyclopropyl-4,5-dihydro-1,3,5-triazin-2-yl)amino)piperidin-2-one(1606973-42-5)

Safety Data

• Hazardous Substances Data: 1606973-42-5(Hazardous Substances Data)

Upstream product

• 1622386-72-4 C₁₂H₉Cl₂N₃ 
• 154148-70-6 5-amino-2-piperidinone 
• 1432056-52-4 3-chloro-N-cyanobenzimidamide 
• 766-84-7 3-chloro-benzonitrile 

Relevant articles and documents

Discovery of triazines as selective PDE4B versus PDE4D inhibitors

In this study we report a series of triazine derivatives that are potent inhibitors of PDE4B. We also provide a series of structure activity relationships that demonstrate the triazine core can be used to generate subtype selective inhibitors of PDE4B versus PDE4D. A high resolution co-crystal structure shows that the inhibitors interact with a C-terminal regulatory helix (CR3) locking the enzyme in an inactive 'closed' conformation. The results show that the compounds interact with both catalytic domain and CR3 residues. This provides the first structure-based approach to engineer PDE4B-selective inhibitors.