1606986-20-2Relevant academic research and scientific papers
Preparation of tetrasubstituted 3-phosphonopyrroles through hydroamination: Scope and limitations
Debrouwer, Wouter,Heugebaert, Thomas S. A.,Stevens, Christian V.
, p. 4322 - 4331 (2014/06/09)
Phosphonylated pyrroles were obtained by a ZnCl2-catalyzed 5-exo-dig hydroamination of propargylic enamines. These starting compounds were obtained in two steps from commercially available β-ketophosphonates. The method tolerates a wide variety of substituents at the 1,2- and 5-position of the pyrrole, while further derivatization allows for the introduction of substituents at the 4-position via lithiation or halogenation.
