1606990-97-9Relevant academic research and scientific papers
An enantioselective inverse-electron-demand imino diels-alder reaction
Eschenbrenner-Lux, Vincent,Kuechler, Philipp,Ziegler, Slava,Kumar, Kamal,Waldmann, Herbert
supporting information, p. 2134 - 2137 (2014/03/21)
The imino Diels-Alder reaction is an efficient method for the synthesis of aza-heterocycles. While different stereo- and enantioselective inverse-electron-demand imino Diels-Alder (IEDIDA) reactions have been reported before, IEDIDA reactions including electron-deficient dienes are unprecedented. The first enantioselective IEDIDA reaction between electron-poor chromone dienes and cyclic imines, catalyzed by zinc/binol complexes is described. The novel reaction provides a facile entry to a natural product inspired collection of ring-fused quinolizines including a potent modulator of mitosis. Copyright
