1606992-86-2Relevant academic research and scientific papers
A diastereoselective one-pot, three-step cascade toward α-substituted allylboronic esters
B?se, Dietrich,Niesobski, Patrik,Lübcke, Marvin,Pietruszka, J?rg
, p. 4699 - 4703 (2014/06/09)
A new highly diastereoselective synthesis of chiral α-substituted allylboronic esters, based on a one-pot, three-step cascade, is presented. The palladium- and acid-cocatalyzed reaction cascade involves a desilylation of a TBS-protected allylic alcohol, borylation, and addition of an allyl group to an aldehyde. Herein we present the first application of a TBS-protected allylic alcohol in a palladium-catalyzed borylation/allylation reaction.
