16071-26-4

Basic information

• Product Name: (R)-2-chloro-diphenylmethanol
• Synonyms: (R)-2-chloro-diphenylmethanol;(alphaR)-2-Chloro-alpha-phenylbenzenemethanol
• CAS NO: 16071-26-4
• Molecular Formula: C₁₃H₁₁ClO
• Molecular Weight: 218.6788
• Mol File: 16071-26-4.mol
• Article Data: 54

Chemical Properties

• Boiling Point: 344.1 °C at 760 mmHg
• Flash Point: 161.9 °C
• Appearance: /
• Density: 1.221
• Vapor Pressure: 2.57E-05mmHg at 25°C
• Refractive Index: 1.609
• PKA: 13.17±0.20(Predicted)
• CAS DataBase Reference: (R)-2-chloro-diphenylmethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-chloro-diphenylmethanol(16071-26-4)
• EPA Substance Registry System: (R)-2-chloro-diphenylmethanol(16071-26-4)

Safety Data

• Hazardous Substances Data: 16071-26-4(Hazardous Substances Data)

Usage

General Description

(R)-2-chloro-diphenylmethanol, also known as R-CDPM, is a chemical compound with the molecular formula C13H11ClO. It is a chiral compound, meaning that it has a non-superimposable mirror image. R-CDPM is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been investigated for its potential use as a chiral auxiliary in organic synthesis. Additionally, R-CDPM has been studied for its antimicrobial and antioxidant properties, making it potentially useful in the development of new drugs and functional materials. Overall, R-CDPM is a versatile chemical with various potential applications in the pharmaceutical and agricultural industries.

InChI:InChI=1/C13H11ClO/c14-12-9-5-4-8-11(12)13(15)10-6-2-1-3-7-10/h1-9,13,15H/t13-/m1/s1

Upstream product

• 5162-03-8 (2-chlorophenyl)(phenyl)methanone 
• 109-72-8 n-butyllithium 
• 64-17-5 ethanol 
• 89-98-5 2-chloro-benzaldehyde 
• 98-80-6 phenylboronic acid 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 694-80-4 2-bromo-1-chlorobenzene 
• 100-52-7 benzaldehyde 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 591-51-5 phenyllithium 
• 949-38-2 1-(benzyloxy)-2-chlorobenzene 
• 95-57-8 2-monochlorophenol 
• 100-39-0 benzyl bromide 
• 100-59-4 phenylmagnesium chloride 

Downstream Products

• 75341-34-3 (2-chlorophenyl)phenylbromomethane 
• 508211-36-7 methyl 2-[(2-chlorophenyl)(phenyl)methoxy]-5-nitrobenzoate 
• 1215280-91-3 C₂₁H₁₆BrCl 
• 16071-25-3 (S)-2-chlorobenzhydrol 
• 1509911-88-9 (E)-(3-(2-chlorophenyl)prop-1-ene-1,3-diyl)dibenzene 
• 4578-81-8 2-(2-chlorophenyl)-2-phenylacetonitrile 

Relevant articles and documents

Bio-inspired asymmetric aldehyde arylations catalyzed by rhodium-cyclodextrin self-inclusion complexes

Transition-metal catalysts are powerful tools for carbon-carbon bond-forming reactions that are difficult to achieve using native enzymes. Enzymes that exhibit inherent selectivities and reactivities through host-guest interactions have inspired widesprea

A Direct Br?nsted Acid-Catalyzed Azidation of Benzhydrols and Carbohydrates

Benzhydryl alcohols were converted into their corresponding diarylazidomethane analogues using azidotrimethylsilane (TMSN3) in the presence of a catalytic amount of a Br?nsted acid HBF4·OEt2. The azidation reactions proceeded in high yields and demonstrated excellent functional group tolerance to electron-donating and electron-withdrawing substituents. In addition, a range of unprotected functional groups including amine, amide, aldehyde and alcohol were well-tolerated. Furthermore, this methodology was successfully applied to carbohydrates for the preparation of the corresponding azide derivatives.

Iodide as a Nucleophilic Trigger in Aryne Three-Component Coupling for the Synthesis of 2-Iodobenzyl Alcohols

The synthetic potential of KI as the iodide source in aryne three-component coupling has been demonstrated using aldehydes as the third component. This mild and transition-metal-free coupling reaction allowed the straightforward synthesis of 2-iodobenzyl alcohols in moderate to good yields with good functional group compatibility. Moreover, KBr and KCl could be used as the nucleophilic trigger in this aryne multicomponent coupling (MCC) and N-methylisatin and CO2 could be used as the electrophilic third components.