160721-25-5

Basic information

• Product Name: ethyl 4-(3-hydroxyphenyl)butanoate
• Synonyms: ethyl 4-(3-hydroxyphenyl)butanoate;Ethyl 4-(3-hydroxyphenyl)butyrate;Benzenebutanoic acid, 3-hydroxy-, ethyl ester
• CAS NO: 160721-25-5
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.255
• Mol File: 160721-25-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 335.5 °C at 760 mmHg
• Flash Point: 140.1 °C
• Appearance: /
• Density: 1.094
• Vapor Pressure: 6.11E-05mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: 2-8°C
• PKA: 10.01±0.10(Predicted)
• CAS DataBase Reference: ethyl 4-(3-hydroxyphenyl)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(3-hydroxyphenyl)butanoate(160721-25-5)
• EPA Substance Registry System: ethyl 4-(3-hydroxyphenyl)butanoate(160721-25-5)

Safety Data

• Hazardous Substances Data: 160721-25-5(Hazardous Substances Data)

Usage

General Description

Ethyl 4-(3-hydroxyphenyl)butanoate, also known as ethyl vanillin, is a chemical compound commonly used as a flavoring agent in the food and beverage industry. It is an ester of the organic compound vanillin and is typically synthesized from guaiacol and acetaldehyde. Ethyl vanillin has a sweet, creamy, and vanilla-like aroma and is often used to enhance the flavor of various food products such as chocolate, baked goods, and beverages. Due to its pleasant scent and taste, ethyl vanillin is also used in the production of perfumes, cosmetics, and pharmaceuticals. This chemical compound is generally regarded as safe for consumption and is approved for use as a food additive by regulatory bodies such as the FDA.

InChI:InChI=1/C12H16O3/c1-2-15-12(14)8-4-6-10-5-3-7-11(13)9-10/h3,5,7,9,13H,2,4,6,8H2,1H3

Upstream product

• 672931-12-3 ethyl 4-[3-(methoxymethoxy)phenyl]butanoate 
• 130604-43-2 ethyl 3-(benzyloxyphenyl)acetate 
• 160721-23-3 <3-(benzyloxy)phenyl>ethanal 
• 22446-38-4 ethyl 3-hydroxyphenylacetate 
• 621-37-4 m-hydroxyphenylacetic acid 
• 160721-24-4 ethyl (E)-4-<3-(benzyloxy)phenyl>-2-butenoate 
• 85090-28-4 (Z)-4-(3-Benzyloxy-phenyl)-but-2-enoic acid ethyl ester 

Downstream Products

• 1357293-82-3 N-(3-chlorophenyl)-4-(3-phenoxyphenyl)butanamide 
• 1357293-85-6 C₁₈H₂₀O₃ 
• 81104-40-7 3-(3-hydroxyphenyl) butanal 
• 143536-28-1 1,8-dihydroxy-1,2,3,4-tetrahydronaphthalene 

Relevant articles and documents

FURAN OR THIOPHENE DERIVATIVE AND MEDICINAL USE THEREOF

The present invention provides a compound represented by the formula (I): [wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or 2, and when p is 2, each R may be the same or different, R1 is a hydrogen atom or an optionally substituted hydrocarbon group, R2 is an optionally substituted aromatic group, Ring A is an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring, X1 is an oxygen atom or a sulfur atom, X2 is a bond, an oxygen atom or -S(O)n- (wherein n is 0, 1 or 2), Y is a bond, an oxygen atom, -S(O)m-, -C(=O)-N(R3)- or -N(R3)-C(=O)- (R3 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is 0, 1 or 2), M1, M2 and M3 may be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon group, and M4 is an optionally substituted divalent aliphatic hydrocarbon group] or a salt thereof, which is useful as a prophylactic and/or therapeutic agent for lipid metabolism abnormality, arteriosclerotic disease and sequelae thereof, diabetes mellitus and the like.

Tandem Reduction / Intramolecular Hydroxyalkylation of (3-Hydroxyphenyl)alkanoates: a New Regioselective Approach to 1,8-Dihydroxytetralins

4-(3-hydroxyphenyl)-butanoates 4, on treatment with DIBALH, followed by hydrolytic work-up, undergo a novel completely regioselective intramolecular hydroxyalkylation reaction to give 1,8-dihydroxytetralins.The yield of the reaction depends heavily on the structure of starting material, best results being achieved with 3,3-disubstituted butanoates.