1607433-29-3Relevant academic research and scientific papers
Ag-Catalyzed Oxidative ipso-Cyclization via Decarboxylative Acylation/Alkylation: Access to 3-Acyl/Alkyl-spiro[4.5]trienones
Reddy, Chada Raji,Kolgave, Dattahari H.,Subbarao, Muppidi,Aila, Mounika,Prajapti, Santosh Kumar
, p. 5342 - 5346 (2020)
A strategy to functionalized spiro[4.5]trienones, by domino silver-catalyzed decarboxylative acylation or alkylation/ ipso-cyclization of N-arylpropiolamides with α-keto acids/alkyl carboxylic acids, is presented. This transformation offers a wide range of substituted 3-acyl/alkyl-spiro[4.5]trienones in high yields with a broad substrate scope. The approach was further extended to access fused tricyclic frameworks, 6,7-dihydro-3H-pyrrolo[2,1-j]quinoline-3,9(5H)-diones.
Metal-free oxidative ipso-carboacylation of alkynes: Synthesis of 3-acylspiro[4,5]trienones from N-arylpropiolamides and aldehydes
Ouyang, Xuan-Hui,Song, Ren-Jie,Li, Yang,Liu, Bang,Li, Jin-Heng
, p. 4582 - 4589 (2014/06/09)
A general and metal-free radical route to synthesis of 3-acylspiro[4,5] trienones is established that utilizes TBHP (tert-butyl hydrogenperoxide) as an oxidation and a reaction partner to trigger the oxidative ipso-carboacylation of N-arylpropiolamides with aldehydes. This method offers a new difunctionalization of alkynes through oxidative cross coupling of the aldehyde C(sp2)-H bond with an ipso-aromatic carbon.
