1607444-05-2Relevant academic research and scientific papers
PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR)
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Page/Page column 35; 55; 56, (2015/02/02)
The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereof wherein Ar', R1, R2, R3, R4, X, Y are as defined in the description of invention, as multi-target directed ligands (MT
Applying a multitarget rational drug design strategy: The first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase
De Simone, Alessio,Ruda, Gian Filippo,Albani, Clara,Tarozzo, Glauco,Bandiera, Tiziano,Piomelli, Daniele,Cavalli, Andrea,Bottegoni, Giovanni
supporting information, p. 4904 - 4907 (2014/05/06)
Combining computer-assisted drug design and synthetic efforts, we generated compounds with potent and balanced activities toward both D3 dopamine receptor and fatty acid amide hydrolase (FAAH) enzyme. By concurrently modulating these targets, our compounds hold great potential toward exerting a disease-modifying effect on nicotine addiction and other forms of compulsive behavior.
