1607447-85-7Relevant academic research and scientific papers
Naphthoquinone-directed C-H annulation and Csp3-H bond cleavage: One-pot synthesis of tetracyclic naphthoxazoles
Wang, Meining,Zhang, Chi,Sun, Li-Ping,Ding, Chunyong,Zhang, Ao
, p. 4553 - 4560 (2014)
One-pot synthesis of tetracyclic naphthoxazole derivatives from electron-deficient naphthoquinones and alkynes was achieved via Rh(III)-catalyzed C-H activation and Csp3-H bond cleavage for the first time. This approach proceeds through a tandem cascade process involving substrate tautomerization, C-H activation, oxidative addition, cyclization, and aromatization. In addition, broad substrate scope, simple starting materials, and steric tolerance make this strategy of great practicality.
