1607449-01-3Relevant academic research and scientific papers
A chiral phosphoric acid catalytic quinoline - 3 - amine asymmetric transfer hydrogenation method of synthesizing chiral ring outside amine
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Paragraph 0027; 0032; 0042, (2018/02/04)
A catalysis system used in a method for synthesizing chiral cyclic amine through catalyzing asymmetric hydrogenation of quinolin-3-amine by chiral phosphoric acid adopts chiral phosphoric acid as a catalyst and substituted 1,4-dihydropyridine (HEH ester) as a hydrogen source. Transfer hydrogenation of simple and easily available substituted quinolin-3-amine is carried out in the system to obtain the cyclic amine compound containing two continuous chiral centers, and the enantiomer excess value can reach 99%. The method has the advantages of simple operation, good diastereoselectivity/enantioselectivity, high yield, and green, atom-economic and environmentally-friendly reaction.
Chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of quinolin-3-amines
Cai, Xian-Feng,Guo, Ran-Ning,Feng, Guang-Shou,Wu, Bo,Zhou, Yong-Gui
, p. 2680 - 2683 (2014/06/09)
A chiral phosphoric acid catalyzed asymmetric transfer hydrogenation of aromatic amines, quinolin-3-amines, was successfully developed with up to 99% ee. To supplement our previous work on the Ir-catalyzed asymmetric hydrogenation of 2-alkyl substituted q
