1607449-05-7

Upstream product

• 1618650-20-6 C₁₅H₁₁FN₂ 
• 98-59-9 p-toluenesulfonyl chloride 
• 1607448-89-4 N-(2-(4-fluorophenyl)quinolin-3-yl)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

A chiral phosphoric acid catalytic quinoline - 3 - amine asymmetric transfer hydrogenation method of synthesizing chiral ring outside amine

A catalysis system used in a method for synthesizing chiral cyclic amine through catalyzing asymmetric hydrogenation of quinolin-3-amine by chiral phosphoric acid adopts chiral phosphoric acid as a catalyst and substituted 1,4-dihydropyridine (HEH ester) as a hydrogen source. Transfer hydrogenation of simple and easily available substituted quinolin-3-amine is carried out in the system to obtain the cyclic amine compound containing two continuous chiral centers, and the enantiomer excess value can reach 99%. The method has the advantages of simple operation, good diastereoselectivity/enantioselectivity, high yield, and green, atom-economic and environmentally-friendly reaction.

Chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of quinolin-3-amines

A chiral phosphoric acid catalyzed asymmetric transfer hydrogenation of aromatic amines, quinolin-3-amines, was successfully developed with up to 99% ee. To supplement our previous work on the Ir-catalyzed asymmetric hydrogenation of 2-alkyl substituted q