1607470-01-8Relevant articles and documents
Synthesis of new simplified hemiasterlin derivatives with α,β-unsaturated carbonyl moiety
The, Chinh Pham,Thi, Tuyet Anh Dang,Hoang, Thi Phuong,Ngo, Quoc Anh,Doan, Duy Tien,Thi, Thu Ha Nguyen,Thi, Tham Pham,Thi, Thu Ha Vu,Jean,Van De Weghe,Van, Tuyen Nguyen
, p. 2244 - 2246 (2014/05/20)
In this Letter, we report a convenient and efficient method for the synthesis of new simplified derivatives of hemiasterlin in which the α,α-dimethylbenzylic moiety A is replaced by α,β- unsaturated aryl groups as Michael acceptor. Most of these derivatives have a strong cytotoxic activity on three human tumor cell lines (KB, Hep-G2 and MCF7). Analogs 17b and 17f showed a high cytotoxicity against KB and Hep-G2 cancer cell lines comparable to paclitaxel and ellipticine.