160749-86-0Relevant academic research and scientific papers
Isoxazolecarboxamide derivatives
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Example 1, (2010/01/31)
The invention relates to novel N-(substituted phenyl)-N′-[ω-(3-substituted phenyl-4-isoxazolecarbonylamino)alkyl]piperazines, their N-oxides, and pharmaceutically acceptable salts thereof. The compounds are endowed with enhanced selectivity for alpha1-adrenergic receptors and a low activity in lowering blood pressure. The compounds are useful in the treatment of obstructive syndromes of the lower urinary tract, including benign prostatic hyperplasia (BPH), and in the treatment of lower urinary tract symptoms (LUTS) and neurogenic lower urinary tract dysfunction (NLUTD), and other conditions.
Phenylpiperazinylalkylamino substituted pyridazinones as potent α1 adrenoceptor antagonists
Barlocco,Cignarella,Dal Piaz,Giovannoni,De Benedetti,Fanelli,Montesano,Poggesi,Leonardi
, p. 2403 - 2410 (2007/10/03)
QSAR models have been used for designing a series of compounds characterized by a N-phenylpiperazinylalkylamino moiety linked to substituted pyridazinones, which have been synthesized. Measurements of the binding affinities of the new compounds toward the
