16078-25-4Relevant articles and documents
Efficient asymmetric hydrogenation of pyridines
Glorius, Frank,Spielkamp, Nick,Holle, Sigrid,Goddard, Richard,Lehmann, Christian W.
, p. 2850 - 2852 (2004)
Up to four stereocenters can be created efficiently in a single step by the asymmetric hydrogenation of oxazolidinone-substituted pyridines (see scheme). Furthermore, selective chirality transfer and nondestructive cleavage of the chiral auxiliary occur under the same reaction conditions, making an additional cleavage step unnecessary.
Synthesis of: N -heterocycles from diamines via H2-driven NADPH recycling in the presence of O2
Al-Shameri, Ammar,Borlinghaus, Niels,Weinmann, Leonie,Scheller, Philipp N.,Nestl, Bettina M.,Lauterbach, Lars
, p. 1396 - 1400 (2019/03/26)
Herein, we report an enzymatic cascade involving an oxidase, an imine reductase and a hydrogenase for the H2-driven synthesis of N-heterocycles. Variants of putrescine oxidase from Rhodococcus erythropolis with improved activity were identified. Substituted pyrrolidines and piperidines were obtained with up to 97% product formation in a one-pot reaction directly from the corresponding diamine substrates. The formation of up to 93% ee gave insights into the specificity and selectivity of the putrescine oxidase.