1607804-93-2Relevant academic research and scientific papers
Synthesis of gem-Difluoromethylene Containing Cycloalkenes via the Ring-Opening Reaction of gem-Difluorocyclopropanes and Subsequent RCM Reaction
Masuhara, Yoshihiro,Tanaka, Toshiki,Takenaka, Hiroaki,Hayase, Shuichi,Nokami, Toshiki,Itoh, Toshiyuki
, p. 5440 - 5449 (2019)
The radical-type ring-opening reaction of gem-difluorocyclopropanes and subsequent regioselective monoepoxidation of the products were demonstrated. Introduction of a vinyl or allyl group to the epoxide produced the diene derivatives that were subjected to the ring closing metathesis reaction to furnish the gem-difluoromethylene containing cyclopentene, cycloheptene, and cyclooctene derivatives in good to excellent yields.
Synthesis of gem-difluoromethylene building blocks through regioselective allylation of gem-difluorocyclopropanes
Munemori, Daisuke,Narita, Kent,Nokami, Toshiki,Itoh, Toshiyuki
, p. 2638 - 2641 (2014/06/09)
gem-Difluorocyclopropane derivatives react with allyltributylstannane in the presence of 2,2′-azobis(isobutyronitrile) to afford 1,6-dienes with a gem-difluoromethylene moiety at the allylic position. The reaction proceeds regioselectively with high yield
