16079-17-7

Basic information

• Product Name: Benzenesulfonamide, N-(1,1-dimethyl-2-propynyl)-4-methyl-
• CAS NO: 16079-17-7
• Molecular Formula: C12H15NO2S
• Molecular Weight: 237.323
• Mol File: 16079-17-7.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-(1,1-dimethyl-2-propynyl)-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-(1,1-dimethyl-2-propynyl)-4-methyl-(16079-17-7)
• EPA Substance Registry System: Benzenesulfonamide, N-(1,1-dimethyl-2-propynyl)-4-methyl-(16079-17-7)

Safety Data

• Hazardous Substances Data: 16079-17-7(Hazardous Substances Data)

Upstream product

• 1010698-14-2 C₁₃H₁₉NO₃S 
• 2978-58-7 1,1-dimethylprop-3-ynylamine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 875612-05-8 (Z)-3-methyl-2-[(dimethyl-phenylsilyl)methylene]-3-(p-tosylamino)butanal 
• 139372-13-7 (Z)-4,4-dimethyl-3-[(dimethyl-phenylsilyl)methylene]-3-(p-tosyl)-1-azetidin-2-one 

Relevant articles and documents

Rhodium-Catalyzed [5+2] Cycloaddition of 3-Acyloxy-1,4-enyne with Alkene or Allene

We recently developed a completely new type of Rh-catalyzed [5+2] cycloaddition by using 3-acyloxy-1,4-enyne (ACE) as the 5-carbon building block. In this update, we show that ACE can undergo intramolecular [5+2] cycloaddition with either an alkene or an allene in the presence of an appropriate rhodium catalyst and ligands to afford bicyclic compounds with multiple stereogenic centers. In most cases, cis-fused bicyclo[5.3.0]decadienes are prepared highly diastereoselectively. (Figure presented.) .

Regioselective Synthesis of Multifunctional Allylic Amines; Access to Ambiphilic Aziridine Scaffolds

We describe, for the first time, a highly regioselective hydrosilylation of propargylic amines. The reaction utilizes a PtCl2/XantPhos catalyst system to deliver hydrosilanes across the alkyne to afford multifunctional allylic amines in high yields. The reaction is tolerant to a wide variety of functional groups and provides high value intermediates with two distinct functional handles. The synthetic applicability of the reaction has been shown through the synthesis of diverse ambiphilic aziridines.

Mechanistic Insights into the Ru(II)-Catalyzed Intramolecular Formal [3 + 2] Cycloaddition of (E)-1,6-Enynes

Design of a unique reaction pathway in transition-metal-catalyzed 1,6-enynes cyclization to construct valuable synthetic motifs is a significant challenge in organic chemistry. Herein, we report a Ru(II)-catalyzed formal [3 + 2] cycloaddition as an efficient method to prepare unprecedented bicyclo[3.3.0]octenes from readily available (E)-1,6-enynes. Mechanistic studies based on the deuterium labeling experiments and the DFT calculation disclose a reasonable mechanistic pathway, where a ruthenacyclopentene generated by an ene-yne oxidative cyclization undergoes a sequential ?-hydride elimination and intramolecular hydroruthenation to form a ruthenacyclohexene, producing the desirable bicyclo[3.3.0]octenes.