160800-57-7
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Basic information
- Product Name: Auristatin E
- Synonyms: Auristatin E
- CAS NO:160800-57-7
- Molecular Formula: C40H69N5O7
- Molecular Weight: 732.00516
- EINECS: N/A
- Product Categories: N/A
- Mol File: 160800-57-7.mol
- Article Data: 0
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Chemical Properties
- Melting Point: 92-94 °C
- Boiling Point: 871.0±65.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.085±0.06 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 13.66±0.20(Predicted)
- CAS DataBase Reference: Auristatin E(CAS DataBase Reference)
- NIST Chemistry Reference: Auristatin E(160800-57-7)
- EPA Substance Registry System: Auristatin E(160800-57-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 160800-57-7(Hazardous Substances Data)
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160800-57-7 Usage
Description
Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; it is a synthetic analog of dolastatin 10. Auristatin E is a highly potent antimitotic agent. Auristatin E inhibits tubulin polymerization(1). Auristatin E-antibody cunjugates have proven to be successful anticancer agents.(2)Ref. 1. Pettit et al. Anticancer Drug Des. 1995 10:529.Ref. 2. Doronina et al. Nature Biotechnol. 2003 21:778.Check Digit Verification of cas no
The CAS Registry Mumber 160800-57-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,0,8,0 and 0 respectively; the second part has 2 digits, 5 and 7 respectively.Calculate Digit Verification of CAS Registry Number 160800-57:
(8*1)+(7*6)+(6*0)+(5*8)+(4*0)+(3*0)+(2*5)+(1*7)=107
107 % 10 = 7
So 160800-57-7 is a valid CAS Registry Number.
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Auristatin E
