160801-88-7Relevant articles and documents
Stereospecific Synthesis of Peptidyl α-Keto Amides as Inhibitors of Calpain
Harbeson, Scott L.,Abelleira, Susan M.,Akiyama, Alan,Barrett, Robert,Carroll, Renee M.,et al.
, p. 2918 - 2929 (2007/10/02)
Peptidyl α-keto amides have been synthesized and tested as inhibitors of the cysteine protease calpain.A stereospecific synthesis was devised in which Cbz-dipeptidyl-α-hydroxy amides were oxidized with TEMPO/hypochlorite to the corresponding α-keto amides