1608084-06-5Relevant academic research and scientific papers
Synthesis of α,β-unsaturated aldehydes based on a one-pot phase-switch dehydrogenative cross-coupling of primary alcohols
Mura, Manuel G.,De Luca, Lidia,Taddei, Maurizio,Williams, Jonathan M. J.,Porcheddu, Andrea
supporting information, p. 2586 - 2589 (2014/06/09)
An efficient one-pot ruthenium-catalyzed hydrogen-transfer strategy for a direct access to α,β-unsaturated aldehydes has been developed. The employment of enolates prepared in situ from alcohols avoided handling unstable aldehydes and provided a very appealing route to different cinnamaldehydes substituted in position 2. A silica-grafted amine was used as phase-switch tag leading to a selective one-pot process in favor of cross-dehydrogenative coupling products.
