16081-47-3Relevant academic research and scientific papers
Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold
Suebsuwong, Chalada,Dai, Bing,Pinkas, Daniel M.,Duddupudi, Anantha Lakshmi,Li, Li,Bufton, Joshua C.,Schlicher, Lisa,Gyrd-Hansen, Mads,Hu, Ming,Bullock, Alex N.,Degterev, Alexei,Cuny, Gregory D.
, (2020/06/08)
Receptor-interacting protein kinase 2 (RIPK2) is a key mediator of nucleotide-binding oligomerization domain (NOD) cell signaling that has been implicated in various chronic inflammatory conditions. A new class of RIPK2 kinase/NOD signaling inhibitors bas
COMPOSITIONS FOR USE IN METHODS OF INHIBITING PROTEIN KINASES
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Paragraph 0016; 0086; 0087; 0096; 0097, (2018/10/25)
Identified compounds demonstrate protein kinase inhibitory activity and inhibition of dependent cell signaling pathways, such as NOD2 cell signaling. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin- like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.
GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES
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, (2015/04/15)
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).
Synthesis of 7-substituted-(2,3-dihydro-1,4-benzodioxin-5-yl)-piperazine
Rancati, Fabio,Bromidge, Steven M.,Del Sordo, Simone,La Rosa, Salvatore,Parini, Carlo,Gagliardi, Stefania
, p. 2507 - 2520 (2008/12/22)
A simple and versatile method for the synthesis of 7-substituted (2,3-dihydro-1,4-benzodioxin-5-yl)-piperazines starting from easy available class of derivatives has been developed. Copyright Taylor & Francis Group, LLC.
BENZOXAZINONE DERIVATIVES, PREPARATION THEREOF AND USES IN THE TREATMENT OF CNS AND OTHER DISORDERS
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Page 54, (2008/06/13)
Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed:wherein A, R1, R2, R3, p, q, A and X are as defined in the specification. Preparation of the compounds and uses in the treatment of CNS and other disorders, including dep
