1608149-56-9Relevant academic research and scientific papers
NOVEL UNCHARGED REACTIVATORS AGAINST OP-INHIBITION OF HUMAN ACETYLCHOLINESTERASE
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Page/Page column 11; 14; 24, (2015/06/08)
The present invention deals with compounds of formula (I) which are novel uncharged reactivators of human acetylcholinesterase, pharmaceutical compositions comprising said compounds, and their use for reactivating human acetylcholinesterase inhibited by a
Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- Aldoxime and -Amidoxime hybrids as efficient uncharged reactivators of nerve agent-Inhibited human acetylcholinesterase
Kliachyna, Maria,Santoni, Gianluca,Nussbaum, Valentin,Renou, Julien,Sanson, Benoit,Colletier, Jacques-Philippe,Arboléas, Mélanie,Loiodice, Mélanie,Weik, Martin,Jean, Ludovic,Renard, Pierre-Yves,Nachon, Florian,Baati, Rachid
supporting information, p. 455 - 467 (2014/05/06)
A series of new uncharged functional acetylcholinesterase (AChE) reactivators including heterodimers of tetrahydroacridine with 3-hydroxy-2-pyridine aldoximes and amidoximes has been synthesized. These novel molecules display in vitro reactivation potencies towards VX-, tabun- and paraoxon-inhibited human AChE that are superior to those of the mono- and bis-pyridinium aldoximes currently used against nerve agent and pesticide poisoning. Furthermore, these uncharged compounds exhibit a broader reactivity spectrum compared to currently approved remediation drugs.
