1608150-41-9

Upstream product

• 1608150-40-8 C₂₄H₂₂BF₂N₅O₂ 
• 336620-03-2 4-formyl-N-methoxy-N-methylbenzamide 
• 619-66-9 4-Carboxybenzaldehyde 
• 910225-64-8 C₇H₁₀N₂O 
• 231609-57-7 2-(2-cyano-1-methylvinylamino)-N-methoxy-N-methylacetamide 
• 26187-28-0 2,4-dimethyl-1H-pyrrole-3-carbonitrile 

Downstream Products

• 1608150-42-0 C₃₅H₃₆BF₂N₅O₃ 
• 1608150-43-1 C₃₁H₂₈BF₂N₅O₃ 

Relevant academic research and scientific papers

Synthesis, evaluation, and biological applications of visible-light-controllable nitric oxide releasers

Nitric oxide (NO) is biologically synthesized in human body and mediates various signal pathway. Because NO is too unstable to handle for biological assay, NO releasers had been developed for NO research. Among them, light-controllable NO releasers are quite useful tool because their NO release can be spatiotemporally controlled by light irradiation. This article shows how to synthesize visible-light controllable NO releasers based on N-nitrosoaminophenol structure, evaluate NO releasing efficiency in various methods, and apply them for biological experiments.

N-NITROSOANILINE DERIVATIVE, NO GENERATOR USING THE SAME, AND GENERATION METHOD OF NO

PROBLEM TO BE SOLVED: To provide an N-nitrosoaniline derivative not containing a poisonous metal, capable of discharging nitrogen monoxide (NO) by irradiation of visible light, and to provide an NO generator using the same, and a generation method of NO. SOLUTION: An N-nitrosoaniline derivative has a pyrromethene boron complex structure shown by following formula 1 synthesized by combining together, for example, 2-(5-amino-2-hydroxyphenyl)-propionate ester, 2,4-dimethyl-3-cyanopyrrole and 4-formylbenzoic acid. COPYRIGHT: (C)2015,JPO&INPIT

Photomanipulation of vasodilation with a blue-light-controllable nitric oxide releaser

Spatiotemporally controllable nitric oxide (NO)-releasers allow us to analyze the physiological effects of NO, a gaseous mediator that modulates many biological signaling networks, and are also candidate chemotherapeutic agents. We designed and synthesized a blue-light-controllable NO releaser, named NOBL-1, which bears an N-nitrosoaminophenol moiety for NO release tethered to a BODIPY dye moiety for harvesting blue light. Photoinduced electron transfer from N-nitrosoaniline to the antenna moiety upon irradiation with relatively noncytotoxic blue light (470-500 nm) should result in NO release with formation of a stable quinone moiety. NO release from NOBL-1 was confirmed by ESR spin trapping and fluorescence detection. Spatially controlled NO release in cells was observed with DAR-4M AM, a fluorogenic NO probe. We also demonstrated temporally controlled vasodilation of rat aorta ex vivo by blue-light-induced NO release from NOBL-1. This compound should be useful for precise examination of the functions of NO with excellent spatiotemporal control.