1608154-00-2Relevant academic research and scientific papers
Facile synthesis of highly substituted 2-pyrone derivatives via a tandem Knoevenagel condensation/lactonization reaction of β-formyl-esters and 1,3-cyclohexadiones
Moghaddam, Firouz Matloubi,Mirjafary, Zohreh,Javan, Marjan Jebeli,Motamen, Sara,Saeidian, Hamid
, p. 2908 - 2911 (2014/05/06)
A mild and efficient tandem process for the synthesis of new highly substituted 2-pyrones starting from commercially available 2-arylacetic acids has been developed. The synthesis is based on the Knoevenagel condensation of 1,3-cyclohexadiones with various β-formyl-esters, followed by lactonization in the presence of nano ZnO (20 mol %). Moderate to high yields and readily available cheap starting materials are the key features of the present method.
