16082-65-8Relevant articles and documents
Cobalt catalyzed electrochemical [4 + 2] annulation for the synthesis of sultams
Cao, Yangmin,Yuan, Yong,Lin, Yueping,Jiang, Xiaomei,Weng, Yaqing,Wang, Tangwei,Bu, Faxiang,Zeng, Li,Lei, Aiwen
, p. 1548 - 1552 (2020/03/26)
Cobalt catalyzed electrochemical [4 + 2] annulation of sulfonamides with alkynes is demonstrated in this work, which provided a practical and environmentally friendly way to synthesize structurally diverse sultams. Notably, by employing anodic oxidation in an undivided cell to recycle the cobalt catalyst, this electrochemical method avoided the utilization of stoichiometric amount of metallic oxidant, delivering H2 as the sole by-product. Moreover, this cobalt catalyzed electrochemical protocol proved to be practical and scalable. When the model reaction was scaled up to 5.0 mmol, 86% yield of product could still be obtained.
Rhodium(i)-catalyzed mono-selective C-H alkylation of benzenesulfonamides with terminal alkenes
Rej, Supriya,Chatani, Naoto
supporting information, p. 10503 - 10506 (2019/09/12)
The Rh(i)-catalyzed ortho-alkylation of benzenesulfonamides with alkenes with the aid of an 8-aminoquinoline directing group is reported. The reaction is applicable to a variety of benzenesulfonamide derivatives and various alkenes. Curiously, unactivated
Small molecule SUMOylation activators are novel neuroprotective agents
Krajnak, Katherine,Dahl, Russell
, p. 405 - 409 (2017/12/26)
Neuronal loss characterizes many of the most intractable nervous system diseases that deprive our ageing population of their quality of life. Neuroprotective pharmacological modalities are urgently needed to address this burgeoning population. Small ubiqu
