16084-32-5Relevant academic research and scientific papers
Bromelain catalyzed synthesis of peptides in organic solvent
Tai, Dar-Fu,Fu, Shu-Lin
, p. 179 - 183 (2007/10/03)
For the first time, immobilized bromelain was shown to maintain high catalytic activity in organic solvent and to form peptide bonds. It requires only 7 hours to obtain Cbz-Gly-L-Leu-OMe in 85% yield. The precursor of aspartame (Cbz-L-Asp-L-Phe-OMe) and other dipeptides were also synthesized by this method.
L-METHIONINE OXIDATION: NOVEL AND UNANTICIPATED TRANSFORMATIONS WITH 4-tBUTYL IODOXYBENZENE
Ranganathan, S.,Ranganathan, D.,Singh, S.K.,Bhattacharyya, D.,Shanthy, S.,Singh, G.P.
, p. 5363 - 5366 (2007/10/02)
4-tButyl iodoxybenzene transforms Bz-Met-OMe to products arising from, S oxidation and C-H insertion followed by degradation.Z-Met(sulfoxide)-OMe is very effective in bringing about ester hydrolysis via intramolecular attack.The S oxidation to sulfoxides and then to sulfones can be monitored and controlled, proceeds with chiral retention, affects neither the peptide bond nor the protecting groups and has been further illustrated with,Z-Gly-Met-OMe, Z-Met-OMe and Z-S(benzyl)-Cys-OMe.
