1608460-72-5Relevant academic research and scientific papers
The cross-selective titanium(III)-catalysed acyloin reaction
Feurer, Markus,Frey, Georg,Luu, Hieu-Trinh,Kratzert, Daniel,Streuff, Jan
, p. 5370 - 5372 (2014)
A titanium(iii)-catalysed intermolecular reductive coupling of ketones or imines with nitriles is described, which gives direct access to α-hydroxylated and α-aminated ketones. This coupling reaction is cross-selective and a catalytic version of the classical acyloin condensation. A reaction mechanism that is supported by first DFT calculations is discussed. the Partner Organisations 2014.
