1608460-87-2Relevant academic research and scientific papers
Targeted phenoxazine porphyrin, preparation method and application of targeted phenoxazine porphyrin as triplet photosensitizer
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Paragraph 0043-0048, (2021/10/11)
The invention discloses targeted phenoxazine porphyrin, a preparation method and application of the targeted phenoxazine porphyrin as a triplet photosensitizer, and relates to the technical field of design, synthesis and application of functional organic molecules. The molecular structure is shown as P in the description. The preparation method comprises the steps of taking aldehyde containing halogen at the tail end as a raw material, and reacting with pyrrole to prepare dipyrrolyl methane; taking phenoxazine as a raw material, and reacting with halogenated aryl aldehyde to generate aldehyde containing phenoxazine; finally, enabling dipyrromethane and aldehyde containing phenoxazine to be subjected to a condensation reaction, and preparing a halogenated porphyrin intermediate; and preparing the phenoxazine porphyrin compound containing a quaternary ammonium salt or quaternary phosphonium salt targeting end by taking tertiary amine or tertiary phosphine as a nucleophilic reagent and carrying out nucleophilic substitution reaction on the tertiary amine or tertiary phosphine and halogenated porphyrin. The targeted phenoxazine porphyrin can generate singlet oxygen under illumination, has good light stability, and can be used as a triplet photosensitizer to be applied to the fields of coloring, photooxidation, photocatalytic organic reaction, photovoltaic cells, photodynamic therapy, lubricating oil oxidation resistance, and metal working fluid sterilization.
A molecular rotor for measuring viscosity in plasma membranes of live cells
López-Duarte, Ismael,Vu, Thanh Truc,Izquierdo, M. Angeles,Bull, James A.,Kuimova, Marina K.
supporting information, p. 5282 - 5284 (2014/05/06)
Molecular rotors have emerged as versatile probes for microscopic viscosity in live cells, however, the exclusive localisation of rotors in the plasma membrane has remained elusive. We report the synthesis, spectroscopic characterisation and live cell imaging of a new BODIPY-based molecular rotor suitable for mapping viscosity in the cell plasma membrane. the Partner Organisations 2014.
