1608473-06-8

Upstream product

• 1262205-99-1 (S,E)-4-[(4-methoxybenzyl)oxy]pent-2-en-1-ol 
• 1608473-12-6 (5S,6S,10R)-10-allyl-5-{(S)-1-[(4-methoxybenzyl)oxy]ethyl}-6-(methoxymethoxy)-12,12,13,13-tetramethyl-2,4,11-trioxa-12-silatetradec-8-yn-7-one 
• 1608472-91-8 C₁₇H₂₆O₇ 
• 1608473-19-3 (2R,3S,4S)-4-[(4-methoxybenzyl)oxy]-2,3-bis(methoxymethoxy)pentan-1-ol 
• 1608473-18-2 (5S,6R)-5-{(S)-1-[(4-methoxybenzyl)oxy]ethyl}-6-(methoxymethoxy)-9,9,10,10-tetramethyl-2,4,8-trioxa-9-silaundecane 
• 1608473-16-0 (2R,3R,4S)-1-[(tert-butyldimethylsilyl)oxy]-4-[(4-methoxybenzyl)-oxy]pentane-2,3-diol 
• 1608473-05-7 (5S,6R,7R,10R)-10-allyl-5-{(S)-1-[(4-methoxybenzyl)oxy]ethyl}-6-(methoxymethoxy)-12,12,13,13-tetramethyl-2,4,11-trioxa-12-silatetradec-8-yn-7-ol 
• 108-24-7 acetic anhydride 
• 122151-36-4 (S)-2-O-(4'-methoxybenzyl)propan-1,2-diol 
• 1608472-94-1 (2R,3R,4S)-4-[(4-methoxybenzyl)oxy]pentane-1,2,3-triol 
• 1608472-93-0 ((2S,3S)-3-{(S)-1-[(4-methoxybenzyl)oxy]ethyl}oxiran-2-yl)methanol 

Relevant academic research and scientific papers

The First Stereoselective Total Synthesis of (-)-Synrotolide

The first stereoselective total synthesis of (-)-synrotolide has been realized by two different approaches, both starting from (S)-ethyl lactate. Both strategies used stereo- and regioselective epoxide opening with a nucleophile, aldehyde alkyne coupling and ring-closing metathesis as key steps. Judicious choice of reagents (CeCl3·7H2O and H2SiF6) for the chemoselective removal of protecting groups delivered the target molecule. The first stereoselective total synthesis of (-)-synrotolide has been accomplished by two different approaches starting from commercially available (S)-ethyl lactate. Both strategies used epoxide opening with hydroxide ion, aldehyde alkyne coupling, and ring-closing metathesis as the key steps. Crucially, chemoselective deprotection of the protecting groups delivered the target molecule.

The first stereoselective total synthesis of (-)-synrotolide

The first stereoselective total synthesis of (-)-synrotolide has been realized by two different approaches, both starting from (S)-ethyl lactate. Both strategies used stereo- and regioselective epoxide opening with a nucleophile, aldehyde alkyne coupling and ring-closing metathesis as key steps. Judicious choice of reagents (CeCl3·7H2O and H 2SiF6) for the chemoselective removal of protecting groups delivered the target molecule. The first stereoselective total synthesis of (-)-synrotolide has been accomplished by two different approaches starting from commercially available (S)-ethyl lactate. Both strategies used epoxide opening with hydroxide ion, aldehyde alkyne coupling, and ring-closing metathesis as the key steps. Crucially, chemoselective deprotection of the protecting groups delivered the target molecule. Copyright