1608483-70-0

Basic information

• Product Name: 8-chloro-4-methyl-2-(4-nitrophenyl)-1H-pyrrolo[3,4-c]quinoline-1,3(2H)-dione
• Synonyms: 8-chloro-4-methyl-2-(4-nitrophenyl)-1H-pyrrolo[3,4-c]quinoline-1,3(2H)-dione
• CAS NO: 1608483-70-0
• Molecular Weight: 367.748
• Mol File: 1608483-70-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-chloro-4-methyl-2-(4-nitrophenyl)-1H-pyrrolo[3,4-c]quinoline-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 8-chloro-4-methyl-2-(4-nitrophenyl)-1H-pyrrolo[3,4-c]quinoline-1,3(2H)-dione(1608483-70-0)
• EPA Substance Registry System: 8-chloro-4-methyl-2-(4-nitrophenyl)-1H-pyrrolo[3,4-c]quinoline-1,3(2H)-dione(1608483-70-0)

Safety Data

• Hazardous Substances Data: 1608483-70-0(Hazardous Substances Data)

Upstream product

• 4835-39-6 N-(4-nitrophenyl)-3-oxobutanamide 
• 17630-76-1 5-chloroindole 2,3-dione 

Relevant articles and documents

Microwave-assisted synthesis of diverse pyrrolo[3,4- c ]quinoline-1,3- diones and their antibacterial activities

With the aim of developing a general and practical method for library production, a novel and efficient two-phase microwave-assisted cascade reaction between isatins and β-ketoamides in [Bmim]BF4/toluene was developed for the synthesis of pyrrolo[3,4-c]quinoline-1,3-diones. The features of this methodology are, the use of microwave-assisted rapid synthesis, mild reaction conditions, high yields, operational simplicity, facile product separation, and recyclability. Furthermore, the antibacterial activities of the pyrrolo[3,4-c]quinoline-1,3-dione derivatives produced were evaluated against Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, and Enterobacter aerogenes) and Gram-positive bacteria (Bacillus cereus and Staphylococcus aureus). These derivatives showed antibacterial activities against Gram-positive strains that were at least equivalent to that against Gram-negative strains. Compound 7{3,5} displayed the most potent antibacterial activity against P. aeruginosa (MIC = 0.5 μg/mL) and greater activity than standard ampicillin (MIC = 1 μg/mL). Compound 7{4,7} exhibited the best inhibitory activity against E. coli and E. aerogenes (MIC = 1 and 0.5 μg/mL), compared with the standard ampicillin (both MICs = 1 μg/mL). The synthesized pyrrolo[3,4-c]quinoline-1,3-diones are expected to be widely used as lead compounds for the development of new antibacterial agents.