1608487-01-9

Basic information

• Product Name: ethyl (S)-6-methyl-4-((4-trifluoromethyl)phenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS NO: 1608487-01-9
• Molecular Weight: 344.358
• Mol File: 1608487-01-9.mol

Chemical Properties

• CAS DataBase Reference: ethyl (S)-6-methyl-4-((4-trifluoromethyl)phenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (S)-6-methyl-4-((4-trifluoromethyl)phenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate(1608487-01-9)
• EPA Substance Registry System: ethyl (S)-6-methyl-4-((4-trifluoromethyl)phenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate(1608487-01-9)

Safety Data

• Hazardous Substances Data: 1608487-01-9(Hazardous Substances Data)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 17356-08-0 thiourea 

Relevant articles and documents

Highly enantioselective Biginelli reaction catalyzed by double axially chiral bisphosphorylimides

Double axially chiral bisphosphorylimides have been used as catalysts in enantioselective Biginelli reactions. The three-component reaction of aromatic aldehydes, thiourea, and ethyl acetoacetate took place by using 5 mol-% catalyst in ethyl acetate at 50°C. A series of chiral dihydropyrimidinethiones (DHPMs) were obtained in high yields (up to 97 %) with good to high enantioselectivities (up to 96 % ee) in only 12 hours. The three-component Biginelli reaction was catalyzed by BINOL-derived double axially chiral bis-phosphorylimides. The catalyst with 3,3′-2-naphthyl substituents most effectively catalyzed the reaction and a series of chiral dihydropyrimidinethiones (DHPMs) were obtained in high yields up to 97 % with 90-96 % ee in only 12 hours. Copyright

Highly Enantioselective Biginelli Reaction Catalyzed by Double Axially Chiral Bisphosphorylimides

Double axially chiral bisphosphorylimides have been used as catalysts in enantioselective Biginelli reactions. The three-component reaction of aromatic aldehydes, thiourea, and ethyl acetoacetate took place by using 5 mol-% catalyst in ethyl acetate at 50 C. A series of chiral dihydropyrimidinethiones (DHPMs) were obtained in high yields (up to 97 %) with good to high enantioselectivities (up to 96 % ee) in only 12 hours.