1608491-35-5Relevant academic research and scientific papers
Nucleophilic phosphine-catalyzed intramolecular michael reactions of N-allylic substituted α-amino nitriles: Construction of functionalized pyrrolidine rings via 5-endo-trig cyclizations
En, Da,Zou, Gong-Feng,Guo, Yuan,Liao, Wei-Wei
supporting information, p. 4456 - 4462 (2014/06/09)
Pyrrolidine rings are common moieties for pharmaceutical candidates and natural compounds, and the construction of these skeletons has received much attention. α-Amino nitriles are versatile intermediates in synthetic chemistry and have been widely used in the generation of multiple polyfunctional structures. Herein, a novel nucleophilic phosphine-catalyzed intramolecular Michael reaction of N-allylic substituted α-amino nitriles has been developed for the efficient construction of functionalized 2,4-disubstituted pyrrolidines (N-heterocyclic α-amino nitriles) via 5-endo-trig cyclization. Furthermore, the one-pot sequence of the synthesis of pyrrolidine and the subsequent transformations of the functionalized products have also been demonstrated.
