160857-22-7Relevant academic research and scientific papers
Synthesis and analgesic activity of new phencyclidine derivatives
Al-Deeb
, p. 1141 - 1144 (2007/10/02)
New phencyclidine derivatives having structural similarities with the well known 4-phenylpiperidine narcotic analgesics were synthesized, characterized and their anti-nociceptive activity tested in mice by the hot-plate and tail-flick tests. Structure, activity relationships for these compounds further point to the importance of a second aryl moiety at position 4 of the piperidine ring of phencyclidine. In addition, the presence of a hydroxyl group in close proximate to the lipophilic moiety is vital for analgesic activity.
