160876-77-7

Upstream product

• 2488-15-5 N-tert-butoxycarbonyl-L-methionine 
• 1738-78-9 L-phenylalanine benzyl ester p-toluene-sulfonic acid salt 
• 2462-32-0 L-phenylalanine benzyl ester hydrochloride 

Downstream Products

• 160876-70-0 (S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-4-methylsulfanyl-butyrylamino]-3-phenyl-propionic acid benzyl ester; compound with trifluoro-acetic acid 
• 160876-90-4 (S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-4-methylsulfanyl-butyrylamino]-3-phenyl-propionic acid benzyl ester 

Relevant academic research and scientific papers

Catalytic dehydrative peptide synthesis with gem-diboronic acids

Alkane-gem-diboronic acids have emerged as versatile organoboron catalysts for dehydrative amidation of α-Amino acids. A phenol-substituted multiboron catalyst with a B-C-B structure outperformed simple arylboronic acids in the condensation of α-Amino acids with suppressed epimerization of electrophiles. gem-diboronic acid catalysis were compatible with various O, N, and S-functionalized α-Amino acids bearing N-protecting groups including common carbamates used in peptide synthesis (Boc, Cbz, Fmoc). N-Trifluoroacetyl protection enabled an unprecedented catalytic dehydrative peptide synthesis at room temperature. Preliminary mechanistic studies revealed carboxylate-binding nature of gem-diboronic acids, orthogonal to the activation of carboxylic acids by arylboronic acids. The distinctive reactivity of the gem-diboronic acids would open prospects for mild catalytic peptide condensation.

Zinc Complexes of Amino Acids and Peptides, 3 . - Zinc Complexes of Peptides with N-terminal Cysteine

Conventional methods were used to prepare three dipeptides Cys-X-OR (X = Gly, Phe), nine dipeptides Cys-X-NH2 (X = Gly, Ala, Val, Leu, Ile, Pro, Phe, Met, Ser), three tripeptides Cys-X-OR (X = Gly-Gly, Phe-Phe, Met-Phe), and three tripeptides Cys-X-NH2 (X