160891-22-5

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 160891-18-9 2-<<(6-amino-1,3-benzodioxol-5-yl)carbonyl>amino>ethanol 
• 40680-63-5 methyl 6-aminobenzo[d][1,3]dioxole-5-carboxylate 
• 57385-14-5 1,3-dioxolo<4,5-g><3,1>benzoxazine-6,8(5H)dione 
• 160891-17-8 6--1,3-benzodioxole-5-carboxylic acid 

Relevant academic research and scientific papers

A new method of preparation of 1,3-dioxolobenzodiazepin-9-ones

Condensation of 1,3-dioxolobenzoxazine-6,8(5H)-dione (3) with 2-aminoethanol/1-amino-2-propanol (4a/b) gives 2-amino>ethanol/isopropanol (5a/b) which on treatment with methanesulphonyl chloride p-toluenesulphonyl chloride at low temperature yields an intermediate 6a-d.Compounds 6a-d on refluxing in ethanol undergo cyclization to furnish 5,6-disubstituted-5,6,7,8-tetrahydro-9H-1,3-dioxolobenzodiazepin-9-ones (7a-d).The structures of various compounds prepared have been confirmed on the basis of IR, PMR and analytical data.