1609003-78-2Relevant academic research and scientific papers
Copper-catalysed: Ortho -selective C-H bond functionalization of phenols and naphthols with α-aryl-α-diazoesters
Ma, Ben,Tang, Zhiqiong,Zhang, Junliang,Liu, Lu
supporting information, p. 9485 - 9488 (2020/09/03)
Herein, we reported the first copper-catalyzed highly efficient C(sp2)-H functionalization of unprotected naphthols and phenols with α-aryl-α-diazoesters. In this transformation, CuCl2 efficiently promoted the highly chemo- and site-selective C-H bond fun
Highly site-selective direct C-H bond functionalization of phenols with α-aryl-α-diazoacetates and diazooxindoles via gold catalysis
Yu, Zhunzhun,Ma, Ben,Chen, Mingjin,Wu, Hai-Hong,Liu, Lu,Zhang, Junliang
supporting information, p. 6904 - 6907 (2014/06/09)
An unprecedented direct C-H bond functionalization of unprotected phenols with α-aryl α-diazoacetates and diazooxindoles was developed. A tris(2,4-di-tert-butylphenyl) phosphite derived gold complex promoted the highly chemoselective and site-selective C-H bond functionalization of phenols and N-acylanilines with gold-carbene generated from the decomposition of diazo compounds, furnishing the corresponding products in moderate to excellent yields at rt. The salient features of this reaction include readily available starting materials, unprecedented C-H functionalization rather than X-H insertion, good substrate scope, mild conditions, high efficiency, and ease in further transformation. To the best of our knowledge, this is the first example of C-H functionalization of unprotected phenols with diazo compounds.
