1609015-94-2Relevant academic research and scientific papers
From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor
Sutton, Jon,Clark, David E.,Higgs, Christopher,De Groot, Marcel J.,Harris, Neil V.,Taylor, Andrea,Lockey, Peter M.,Maubach, Karen,Woodrooffe, Amanda,Davis, Richard J.,Coleman, Robert A.,Clark, Kenneth L.
, p. 2212 - 2221 (2014)
In this Letter, we present the results of a hit-finding and lead optimization programme against the EP4 receptor (EP4R). In a short time period, we were able to discover five structurally diverse series of hit compounds using a combi
