160906-87-6Relevant academic research and scientific papers
Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists
Cole, Derek C.,Lennox, William J.,Lombardi, Sabrina,Ellingboe, John W.,Bernotas, Ronald C.,Tawa, Gregory J.,Mazandarani, Hossein,Smith, Deborah L.,Zhang, Guoming,Coupet, Joseph,Schechter, Lee E.
, p. 353 - 356 (2005)
5-Arylsulfonylamido-3-(pyrrolidin-2-ylmethyl)-1H-indoles have been identified as high-affinity 5-HT6 receptor ligands. Within this class, several of the (R)-enantiomers were potent agonists having EC 50 values of 1 nM or less and functioning as full agonists while the (S)-enantiomers displayed moderate antagonist activity.
