1609074-03-4

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 1197-09-7 1-(3,4-dihydroxyphenyl)ethan-1-one 
• 21038-22-2 O-(4-methoxybenzyl)hydroxylamine 
• 1609071-95-5 2-(3,4-bis((4-methoxybenzyl)oxy)phenyl)-2-oxoacetic acid 

Relevant academic research and scientific papers

2 - Substituted cephem compound-containing pharmaceutical composition

PROBLEM TO BE SOLVED: To provide a cephem compound which has a strong antimicrobial activity, in particular effective against various β-lactamase producing Gram negative bacteria, and a composition comprising the compound.SOLUTION: The present invention provides a pharmaceutical composition comprising a compound represented by formula (I), an ester at a carboxyl group, an amino-protected compound when the amino is present on a ring in the 7-side chain, or a pharmaceutically acceptable salt thereof.

2 SUBSTITUTED CEPHEM COMPOUNDS

The compounds of formula (I) of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.