1609087-17-3Relevant academic research and scientific papers
Catalytic enantioselective synthesis of (S)-8-hydroxy-3-[(S)-2′- hydroxypentyl]-6-methoxyisochroman-1-one, (S)-3-Hydroxy-3-[(S)-2′- hydroxypentyl]-6,8-dimethoxyisochroman-1-one, and their epimers
Kumaraswamy, Gullapalli,Ankamma, Kukkadapu,Raghu, Nimmakayala,Rambabu, Dasa
, p. 2168 - 2173 (2014)
The total synthesis of (S)-8-hydroxy-3-[(S)-2′-hydroxypentyl]-6- methoxyisochroman-1-one, (S)-3-hydroxy-3-[(S)-2′-hydroxypentyl]-6,8- dimethoxyisochroman-1-one, and their epimers has been successfully achieved. The key reactions include a catalytic enantioselective asymmetric epoxidation to introduce the chirality, and an Alder-Rickert reaction for the construction of the substituted phenyl ring. Copyright
