160909-98-8Relevant academic research and scientific papers
Total Synthesis of (-)-Ambrox from S-(+)-Carvone (part 6)
Verstegen-Haaksma, Anja A.,Swarts, Henk J.,Jansen, Ben J. M.,Groot, Aede de
, p. 10095 - 10106 (2007/10/02)
Conjugate addition of cyanide and allyl nucleophiles to S-(+)-carvone followed by annulation with methyl vinyl ketone gave the substituted decalones 2 and 3 stereoselectively.Both decalones were transformed into (-)-Ambrox via modification of the sidechain, methylation, conversion of the isopropenyl group and cyclization.
