16091-98-8

Upstream product

• 828-51-3 1-Adamantanecarboxylic acid 
• 351464-84-1 (3r,5r,7r)-N-methoxy-N-methyladamantane-1-carboxamide 
• 1660-04-4 1-acetyladamantane 

Downstream Products

• 39269-10-8 adamantane-1,3-dicarboxylic acid 
• 361442-00-4 (αS)-α-[[(1,1-dimethylethoxy)carbonyl]-amino]-3-hydroxytricyclo[3.3.1.1^3,7]decane-1-acetic acid 
• 59768-71-7 2-(adamantan-1-yl)-2-aminoacetic acid 
• 709031-29-8 3-hydroxy-1-adamantyl-glycine 
• 709031-28-7 3-hydroxy-α-oxotricyclo [3.3.1.1^3,7]decane-1-acetic acid 

Relevant academic research and scientific papers

A novel method for the synthesis of 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid

A simple and efficient synthetic route to 2-(3-hydroxy-1-adamantyl)-2- oxoacetic acid is described by a direct oxidation reaction of adamantan-1-yl-ethan-1-one which could be prepared by a Grignard reaction. In this approach, the oxidation reaction introduced the hydroxyl and carboxyl group by a one-pot reaction.

PROCESS FOR THE PREPARATION OF ADAMANTANE DERIVATIVES

The invention relates to a process for the preparation of 3-hydroxyadamantaneglyoxylic acid of the general formula (1) or a derivative or salt thereof. In the process, an 1-acyl derivative of adamantane having the formula (2): wherein R is a C1-C5 hydrocarbyl; CH2OH; CHO; COOH, is contacted with an oxidant under oxidizing conditions leading to the 3-hydroxyadamantaneglyoxylic acid (1) or the derivative or salt thereof.

Eliminative Ring Fission of 1,2,4-Trioxan-5-ones. A New Approach to α-Keto Acids

6-Mono-R-substituted 1,2,4-trioxan-5-ones readily undergo base-catalysed O-O bond cleavage to furnish α-keto acids (RCOCOOH) in high yields even when the R-substituents are bulky.