1609114-26-2Relevant academic research and scientific papers
Diastereo- and enantioselective michael addition of 3-substituted oxindoles to trifluoromethyl-substituted nitro olefins catalyzed by a cinchona-alkaloid-derived squaramide
Zhao, Mei-Xin,Ji, Fei-Hu,Zhao, Xiao-Li,Han, Ze-Zheng,Shi, Min
, p. 644 - 653 (2014/02/14)
Highly efficient diastereo- and enantioselective Michael addition reactions between 3-substituted oxindoles and trifluoromethylated nitro olefins catalyzed by a quinine-derived squaramide have been investigated. The corresponding adducts, each bearing a chiral tertiary carbon center attached to a trifluoromethyl group and adjacent to a quaternary stereocenter at the C3 position of the oxindole, were obtained in good to excellent yields (up to 99 %) and with high diastereoselectivities (up to >20:1 dr) and excellent enantioselectivities (up to 99 % ee). We have developed highly effective diastereo- and enantioselective Michael additions of 3-substituted oxindoles to trifluoromethylated nitro olefins catalyzed by a quinine-derived squaramide catalyst. The corresponding adducts are obtained in good to excellent yields (up to 99 %) along with high diastereoselectivities (up to >20:1 dr) and excellent enantioselectivities (up to 99 % ee). Copyright
Diastereo- and Enantioselective Michael Addition of 3-Substituted Oxindoles to Trifluoromethyl-Substituted Nitro Olefins Catalyzed by a Cinchona-Alkaloid-Derived Squaramide
Zhao, Mei-Xin,Ji, Fei-Hu,Zhao, Xiao-Li,Han, Ze-Zheng,Shi, Min
, p. 644 - 653 (2015/10/05)
Highly efficient diastereo- and enantioselective Michael addition reactions between 3-substituted oxindoles and trifluoromethylated nitro olefins catalyzed by a quinine-derived squaramide have been investigated. The corresponding adducts, each bearing a chiral tertiary carbon center attached to a trifluoromethyl group and adjacent to a quaternary stereocenter at the C3 position of the oxindole, were obtained in good to excellent yields (up to 99 %) and with high diastereoselectivities (up to >20:1 dr) and excellent enantioselectivities (up to 99 % ee).
